Author
Institute of Structural and Molecular BiologyORCID 0000-0001-9992-8375Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Alexander J. D. Snow, Tharushi Wijesiriwardena, Benjamin J. Lane…·Alexander L. Breeze
This paper expresses and functionally characterizes the oncogenic RTK FGFR3-TACC3 using cell-free protein expression, achieving significant kinase activity.
Daniel N. Bull, Julie C. Matte, Carmen M. Navarrón…·Lorenza Magno
This study investigates the effects of the PLCγ2 S707Y hypermorphic variant on human microglia, showing increased enzymatic activity but reduced phagocytosis and cytokine production, and suggests therapeutic strategies should mimic the beneficial effects of the P522R variant.
Lorenza Magno, Christian B. Lessard, Marta Martins…·Paul John Whiting
The paper confirms that the PLCG2 P522R variant is protective against Alzheimer’s disease and shows it weakly activates PLCG2 enzyme function in microglia.