Author

Christian B. Lessard

University of Florida

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

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Approach:statistical model· 4 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:Drosophila· 1

Frequent Co-Authors

Paramita ChakrabartyiD· 4 shared Stefan ProkopiD· 3 shared Todd Eliot GoldeiD· 3 shared Jennifer Phillips· 2 shared Jose Francisco AbisambraiD· 2 shared Karen N. McFarlandiD· 2 shared Marangelie Criado‐MarreroiD· 2 shared Sakthivel RaviiD· 2 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Paramita ChakrabartyORCID

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4 papers

Recent·Most cited

PERK Deficiency Amplifies Molecular, Structural, and Network Vulnerability to Repetitive Mild Traumatic Brain Injury

Marangelie Criado‐Marrero, Sakthivel Ravi, Daylin Barroso, Tristyn N. Garza, Diana Marcela Cuestas Torres, Christian B. Lessard, Juan Pablo Castaño, MacKenzie L. Bolen, Uriel Rubinovich, Stefan Prokop, Paramita Chakrabarty, Laura P.W. Ranum, Marcelo Febo, Jose Francisco Abisambra

This study shows that PERK deficiency worsens molecular, structural, and network damage in mice after repetitive mild traumatic brain injury.

Neurobiology of Disease · Jul 11, 2026Peer-reviewedNeuroscience

Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity

Christian B. Lessard, Diego Rubio-Rubio, Samantha G Tolton, Marangelie Criado‐Marrero, Sakthivel Ravi, Tristyn N. Garza, John Koren, Jennifer Phillips, Pritha Bagchi, Karen N. McFarland, Deepak Chhangani, Todd Eliot Golde, Benoit I. Giasson, Jada M. Lewis, Paramita Chakrabarty, , Jose Francisco Abisambra

This study identifies a PERK-B/DLX1 pathway as a novel driver of tau pathology in human PSP and flies, showing DLX1 promotes tau toxicity.

bioRxiv · Jun 30, 2025 · PreprintNeuroscience

Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways

Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, Elsa Gonzalez De La Cruz, Shivani Shah, Quan Vo, Xue Wang, Zachary Quicksall, Daniel H. Ryu, Cory C. Funk, Nilüfer Ertekin‐Taner, Stefan Prokop, , Paramita Chakrabarty

This study shows that deletion of Abi3/Gngt2 affects amyloid β and tau pathologies differently with age in AD models.

Alzheimer s Research & Therapy · Jul 27, 2022Peer-reviewedNeuroscience

Alzheimer’s disease Phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

Lorenza Magno, Christian B. Lessard, Marta Martins, Verena Lang, Pedro E. Cruz, Yasmine T. Asi, Matilda Katan, Jamie Bilsland, Tammaryn Lashley, Paramita Chakrabarty, Todd Eliot Golde, Paul John Whiting

The paper confirms that the PLCG2 P522R variant is protective against Alzheimer’s disease and shows it weakly activates PLCG2 enzyme function in microglia.

Alzheimer s Research & Therapy · Feb 2, 2019Peer-reviewedNeuroscience