Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
Peyton C. High, Zhengdong Liang, Cara Guernsey-Biddle, Shraddha Subramanian, Yueh-Ming Shyu, Adela M. Aldana, Yukimatsu Toh, Kendra S. Carmon
This study shows cetuximab increases LGR5 expression and improves the efficacy of LGR5-targeting ADCs in colorectal cancer models.
Cell Reports Medicine · Sep 23, 2025Peer-reviewedCancer Biology