Kouros Owzar

A nonhuman primate model mirrors human congenital cytomegalovirus infection and reveals a spectrum of vertical transmission outcomes

The nonhuman primate model mirrors the epidemiology of human congenital CMV (cCMV) after primary infection and reveals its transmission bottlenecks.

TEMPTED: Time-Informed Dimensionality Reduction for Longitudinal Microbiome Studies

TEMPTED improves analysis of longitudinal microbiome data by incorporating time as a continuous variable, achieving high accuracy in phenotype classification and identifying microbial markers linked to birth outcomes.

Common variation in a long non-coding RNA gene modulates variation of circulating TGF-β2 levels in metastatic colorectal cancer patients (Alliance)

The paper identifies a novel cis-pQTL in LINC02869 associated with TGF-β2 levels in mCRC patients and validates it in prostate cancer patients.

SifiNet: A robust and accurate method to identify feature gene sets and annotate cells

SifiNet identifies gene sets and annotates cells without clustering, showing better performance than existing methods on multiomic data.

DYNATE: Localizing Rare-Variant Association Regions via Multiple Testing Embedded in an Aggregation Tree

DYNATE identifies rare-variant association regions by dynamically aggregating genomic regions and controlling false discovery rate, finding a new ALS-associated gene.

Clustering Deviation Index (CDI): A robust and accurate unsupervised measure for evaluating scRNA-seq data clustering

This paper introduces CDI, a new unsupervised measure to evaluate scRNA-seq clustering accuracy and select optimal parameters.

Exploiting expression patterns across multiple gene isoforms to identify radiation response biomarkers in early-stage breast cancer patients.

The paper introduces two statistical methods to identify radiation response biomarkers in early-stage breast cancer by analyzing gene isoform expression patterns.