Clara Reasoner

Pathogenesis and host response to a novel Tacaribe virus isolate in experimentally-infected Jamaican fruit bats

This paper isolates and characterizes a novel Tacaribe virus (TCRV) strain from Jamaican fruit bats, showing it causes nonfatal infection with mild liver disease and limited immune response, offering a better model for studying arenavirus biology than previously used strains.

Low cadmium concentrations alter B and T cell responses in Jamaican fruit bats (Artibeus jamaicensis)

This study shows that low cadmium exposure alters B and T cell gene expression in Jamaican fruit bats, suggesting immune system changes, but not affecting viral replication in kidney cells.

Cellular and Immune Adaptations at the Maternal-Fetal Interface in Bats

This study uses single-nucleus RNA sequencing and organoids to identify unique placental cell types and immune adaptations in Jamaican fruit bats, revealing species-specific gene programs and attenuated antiviral responses in trophoblasts.

Back to basics: Immunoglobulin germline reference sequences enable investigations and reveal insights into bat-specific immunity

The paper generates a bat genome and germline immunoglobulin loci to study B cell receptors, finding unique features and differences compared to humans.

ELAVL1 Primarily Couples mRNA Stability with the 3'UTRs of Interferon Stimulated Genes

This study identifies ELAVL1's context-dependent binding sites and regulatory role in immune activation by integrating multiple high-throughput approaches.