Carolyn B. Coyne

This study investigates the differential roles of type I and III interferons in antiviral defense and epithelial integrity at the choroid plexus using organoid models and single-cell RNA sequencing.

This study identifies IFN{varepsilon} as a constitutively expressed IFN that maintains antiviral defenses in the female reproductive tract and intestine by sustaining specific epithelial states and type III IFN expression.

This study shows that TLR3 in villus-like enterocytes drives IFN-III responses to enteroviruses, highlighting their role in antiviral defense.

This study develops a mouse model of echovirus infection and identifies humoral correlates of protection against the virus.

This study shows that Toxoplasma gondii infection redirects placental trophoblast lineage specification, promoting infection-permissive cells over infection-resistant ones.

This study uses single-nucleus RNA sequencing and organoids to identify unique placental cell types and immune adaptations in Jamaican fruit bats, revealing species-specific gene programs and attenuated antiviral responses in trophoblasts.

This study compares rhesus macaque and human placental organoids to identify evolutionary differences in trophoblast gene expression and differentiation pathways.

This study uses spatial transcriptomics and organoids to define cellular diversity at the swine maternal-fetal interface, revealing conserved trophoblast populations and novel markers.

The paper identifies DUX4-stimulated genes as an antiviral defense program in human trophoblasts, specifically targeting herpesviruses through an alternative pathway to the IFN response.

This study identifies Kupffer cells and dendritic cells as key sources of type I IFN during echovirus infection, showing their role in liver immunity and pathogenesis.

The paper compares trophoblast differentiation in fetal membranes and chorionic villi using organoids and RNA sequencing, finding region-specific gene expression patterns influenced by environmental cues.

This study compares syncytiotrophoblast gene expression in placental tissue and trophoblast organoids using snRNA-seq, identifying distinct nuclear subtypes and environmental influences on STB gene expression.

The paper identifies a human protein of retroviral origin that restricts retroviral infection, showing its expression in embryos and placenta and its antiviral activity against type D retroviruses.

This study identifies BPIFB3 as a host factor that facilitates flavivirus infection by regulating RETREG1-dependent reticulophagy.