Author

Rebecca L. Casazza

Duke UniversityORCID 0000-0002-8271-6947Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Carolyn B. CoyneiD· 2 shared Allyson CaldwelliD· 1 shared Ashley HigginsiD· 1 shared Celeste R. RoblesiD· 1 shared Clara ReasoneriD· 1 shared Cole R. McCutcheoniD· 1 shared David N. HareiD· 1 shared Erika Zhan· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

Carolyn B. CoyneORCID

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3 papers

Recent·Most cited

Constitutive Interferon Epsilon Expression Shapes Antiviral Epithelial States in the Female Reproductive Tract and Intestine

Rebecca L. Casazza, Samantha Skavicus, David N. Hare, Kaila A Cooley, Nicholas S. Heaton, Carolyn B. Coyne

This study identifies IFN{varepsilon} as a constitutively expressed IFN that maintains antiviral defenses in the female reproductive tract and intestine by sustaining specific epithelial states and type III IFN expression.

mBio · May 5, 2026Peer-reviewedImmunology

Interferon lambda signaling to maternal dendritic cells protects against congenital Zika virus infection

Margaret R. Dedloff, Thomas R. Reinhardt, Tessa‐Jonne F. Ropp, Joel Rivera-Cardona, Celeste R. Robles, Rebecca L. Casazza, Jennifer Ashley Ezzell, Michelle S. Itano, Helen M. Lazear

This study shows that maternal IFN-lambda signaling to dendritic cells reduces transplacental ZIKV transmission in mice.

bioRxiv · Jan 27, 2026 · PreprintImmunology

Cellular and Immune Adaptations at the Maternal-Fetal Interface in Bats

Allyson Caldwell, Liheng Yang, Rebecca L. Casazza, Rizban E Worota, Cole R. McCutcheon, Patrick S. Creisher, Erika Zhan, Clara Reasoner, Ashley Higgins, Tony Schountz, Carolyn B. Coyne

This study uses single-nucleus RNA sequencing and organoids to identify unique placental cell types and immune adaptations in Jamaican fruit bats, revealing species-specific gene programs and attenuated antiviral responses in trophoblasts.

Cell Reports · Dec 1, 2025Peer-reviewedDevelopmental Biology