The paper evaluates statistical methods for differential metaproteomics, finding that several approaches effectively identify differentially abundant proteins despite data challenges.

bioRxiv · Jun 8, 2026 · PreprintMolecular Biology

Critical Assessment of MetaProteome Investigation 2 (CAMPI-2): Multi-laboratory assessment of sample processing methods to stabilize fecal microbiome for functional analysis

Alessandro Tanca, Kay Schallert, Lucia Grenga, Samantha L. Peters, Marcello Abbondio, Laura De Diego, Maria Antonietta Deledda, Sven‐Bastiaan Haange, Guylaine Miotello, Johan S. Sáenz, Maximilian Wolf, Felipe Bastida, Simon Devos, Guillermina Hernandez‐Raquet, Jana Seifert, , Sergio Uzzau

CAMPI-2 evaluates five fecal sample stabilization methods for metaproteomics, finding one commercial device offers the best reproducibility and stability during room-temperature storage.

Microbiome · Nov 27, 2025Peer-reviewedMicrobiology

Integrated multi-omics highlights alterations of gut microbiome functions in prodromal and idiopathic Parkinson's disease

Rémy Villette, Júlia Ortís Sunyer, Polina V. Novikova, Velma T. E. Aho, В. А. Петров, Oskar Hickl, Susheel Bhanu Busi, Charlotte De Rudder, Benoit Josef Kunath, Anna Heintz‐Buschart, Jean‐Pierre Trezzi, Rashi Halder, Christian Jäger, Laura Lebrun, Annegrät Daujeumont, , Paul Wilmes

The paper uses integrated multi-omics to identify functional gut microbiome alterations in Parkinson's disease and prodromal stages, finding changes in metabolites and microbial gene transcripts.

Microbiome · Oct 6, 2025Peer-reviewedSystems Biology