Author

Elise K. Phillips

Oak Ridge National LaboratoryORCID 0000-0002-3361-7475Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Carrie A. EckertiD· 2 shared Dawn M. KlingemaniD· 2 shared William G. AlexanderiD· 2 shared Adam M. GussiD· 1 shared Rick HarrisoniD· 1 shared S’Khaja CharlesiD· 1 shared Timothy D. WiseriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

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2 shared papersSynthetic Biology

Carrie A. EckertORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintMay 23, 2025

When good guides go bad: empirical evaluation of all unique Cas9 targets in E. coli reveal widespread functionality and rules for gRNA design

Elise K. Phillips, Rick Harrison, S’Khaja Charles…·William G. Alexander

The paper evaluates nearly 500,000 unique gRNAs in E. coli, finding most are functional and identifying rules to improve gRNA design.

DOI 10.1101/2025.05.23.651106

E. coliCRISPR screen

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Synthetic BiologybioRxivPreprintMay 12, 2025

Multilayered regulation by RNA thermometers enables precise control of Cas9 expression

Elise K. Phillips, Dawn M. Klingeman, Adam M. Guss…·William G. Alexander

The paper demonstrates that RNA thermometers can reduce Cas9-induced cell death by controlling its expression through temperature-dependent regulation.

1 citation

CRISPR screenexperimental assay

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