Carrie A. Eckert

The paper evaluates nearly 500,000 unique gRNAs in E. coli, finding most are functional and identifying rules to improve gRNA design.

The paper demonstrates that RNA thermometers can reduce Cas9-induced cell death by controlling its expression through temperature-dependent regulation.

This study uses CRISPRi screens to identify transcriptional gradients in Synechococcus sp. PCC 7002 that improve growth under cold monochromatic light conditions.

The paper introduces MIJAMP, a software tool to identify methylated DNA motifs from nanopore sequencing data, validated using genome-wide methylation data.

The paper develops a split ribozyme-based biosensor for in vivo visualization of gene expression in plants, demonstrating its use in transient expression and endogenous gene expression in Arabidopsis thaliana.

This study improves gene expression and transformation efficiency in Picosynechococcus sp. PCC 7002 by optimizing protocols and identifying a better integration site.

This paper develops a novel feature set and public resource for predicting CRISPR-Cas9 sgRNA efficiency using quantum chemical tensors and explainable-AI methods.