BiophysicsPNAS NexusPeer-reviewed
The fully activated open state of KCNQ1 controls the cardiac 'fight-or-flight' response
Panpan Hou, Lu Zhao, Ling Zhong…·Jianmin Cui
This paper identifies the fully activated open state of KCNQ1 as critical for β-adrenergic stimulation of IKs channels, showing that modulators enhancing this state can restore function in LQT1 mutants.
6 citations