Author

Michael K. Gilson

University of California San DiegoORCID 0000-0002-3375-1738Unclaimed ORCID profile · follow to get notified of new preprints

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Michael K. Gilson2 papers

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:large language model· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Danielle Ann GrotjahniD· 2 shared Digvijay SinghiD· 2 shared Li ZhangiD· 2 shared Pengtao XieiD· 2 shared Trey E. IdekeriD· 2 shared Atul MalhotraiD· 1 shared Chengzhan Gao· 1 shared David R. SlochoweriD· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersBioinformatics

Danielle Ann GrotjahnORCID

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3 papers

Recent·Most cited

ProteinAligner: A Multi-modal Pretraining Framework for Protein Foundation Models

Li Zhang, Han Wen Guo, Leah V. Schaffer, Young Su Ko, Digvijay Singh, Hamid Rahmani, Danielle Ann Grotjahn, Elizabeth Villa, Michael K. Gilson, Wei Wang, Trey E. Ideker, Eric P. Xing, Pengtao Xie

ProteinAligner improves protein function and property prediction by integrating sequence, structure, and literature text modalities in a multi-modal pretraining framework.

bioRxiv · Oct 6, 2024 · PreprintBioinformatics

Multi-Modal Large Language Model Enables All-Purpose Prediction of Drug Mechanisms and Properties

Youwei Liang, Ruiyi Zhang, Yongce Li, Mingjia Huo, Zinnia Ma, Digvijay Singh, Chengzhan Gao, Hamidreza Rahmani, Satvik Bandi, Li Zhang, Robert Neal Weinreb, Atul Malhotra, Danielle Ann Grotjahn, Linda Awdishu, Trey Ideker, , Pengtao Xie

DrugChat, a multi-modal LLM, predicts drug mechanisms and properties through free-form text, outperforming GPT-4 and specialized models in accuracy and versatility.

bioRxiv · Sep 29, 2024 · PreprintPharmacology & Toxicology

Motor-Like Properties of Non-Motor Enzymes

David R. Slochower, Michael K. Gilson

The paper investigates whether non-motor enzymes exhibit motor-like properties by simulating energy surfaces and analyzing directional probability flows in three enzymes.

bioRxiv · Feb 7, 2018 · PreprintBiophysics