Ruiyi Zhang

A Population-scale Single-cell Spatial Transcriptomic Atlas of the Human Cortex

This study creates a single-cell spatial transcriptomic atlas of the human cortex, revealing gene expression patterns, aging effects, and disease associations across layers and species.

Dorsolateral prefrontal cortex drives strategic aborting by optimizing long-run policy extraction

The paper shows macaques strategically abort rewards in a VR task to maximize long-term gains, with dlPFC activity reflecting this behavior.

Multi-Modal Large Language Model Enables All-Purpose Prediction of Drug Mechanisms and Properties

DrugChat, a multi-modal LLM, predicts drug mechanisms and properties through free-form text, outperforming GPT-4 and specialized models in accuracy and versatility.

Spatially resolved molecular and cellular atlas of the mouse brain

The paper creates a high-resolution spatial transcriptomic atlas of the mouse brain using snRNA-seq and Stereo-seq, identifying new cell clusters, region-specific genes, and transcription factor regulons.

scPretrain: Multi-task self-supervised learning for cell type classification

scPretrain improves cell type classification by using self-supervised learning with both annotated and unannotated cells across 60 datasets.