Robert Neal Weinreb

This paper shows that AAV2-hAIBP preserves retinal ganglion cells and visual function in glaucoma without lowering intraocular pressure by targeting neuroinflammation through the AIBP-TLR4 axis.

This study identifies 207 height-associated genes using rare protein-altering variants from over 1.4 million individuals, showing large effect sizes and overlap with Mendelian height syndromes.

This paper develops a polygenic risk score for glaucoma with improved performance across major ancestries, enabling earlier detection and targeted treatment of high-risk individuals.

The paper identifies AKAP1 as a critical regulator of mitochondrial and synaptic homeostasis in glaucoma, showing its role in neuroprotection and axon regeneration through gene therapy in mouse models.

This study shows that restoring AIBP expression in glaucomatous retinas protects retinal ganglion cells and reduces neuroinflammation in mouse models.

DrugChat, a multi-modal LLM, predicts drug mechanisms and properties through free-form text, outperforming GPT-4 and specialized models in accuracy and versatility.

This study shows that activating soluble adenylyl cyclase (sAC) protects retinal ganglion cells from oxidative stress by preserving mitochondrial function and structure.

This study shows that repeated stress in young mice accelerates retinal aging at the transcriptional and epigenetic levels, highlighting the importance of early intervention for age-related eye diseases.

This study shows that loss of AKAP1 leads to Drp1 dephosphorylation, mitochondrial fragmentation, and RGC dysfunction in glaucoma, suggesting AKAP1 as a therapeutic target.

The paper shows that removing senescent cells early in a mouse model of ocular hypertension protects retinal ganglion cells from loss and preserves visual function.