Shinsuke Koike

Genetic and epigenetic regulation of SLC6A4 shapes vulnerability to cognitive decline and depressive tendency in later life

This study shows that genetic and epigenetic regulation of SLC6A4 influences vulnerability to cognitive decline and depressive symptoms in older adults.

High-Frequency Activity Encodes the Temporal Dynamics of Hierarchical Prediction Errors in Humans: An Electrocorticography Study

This study uses ECoG to examine high-frequency neural activity in humans during auditory sequences, showing that both local and global prediction errors are encoded in high-frequency oscillations.

Computational Mechanisms of Neuroimaging Biomarkers Uncovered by Multicenter Resting-State fMRI Connectivity Variation Profile

The paper develops a method to profile resting-state fMRI connectivity variations to improve the reliability and generalizability of psychiatric disorder biomarkers across multiple centers.

Unsupervised feature computation-based feature selection robustly extracted resting-state functional connectivity patterns related to mental disorders

This study compares unsupervised feature selection with supervised methods to identify robust resting-state functional connectivity patterns associated with psychiatric disorders.

Chronic social defeat causes dysregulation of systemic glucose metabolism via the cerebellar fastigial nucleus

This study shows chronic social defeat stress in mice causes metabolic dysregulation through cerebellar pathways, linking psychological stress to type II diabetes.

Crossmodal Hierarchical Predictive Coding for Audiovisual Sequences in Human Brain

This study investigates crossmodal predictive coding in the human brain using EEG during an audiovisual oddball paradigm, finding that audiovisual integration occurs at both local and global levels.

Dissecting Mismatch Negativity: Early and Late Subcomponents for Detecting Deviants in Local and Global Sequence Regularities

The paper investigates MMN subcomponents by analyzing EEG data from an auditory oddball paradigm, finding two distinct subcomponents linked to local and global sequence regularities.

Normative modeling of brain morphometry in Clinical High-Risk for Psychosis

This study examines brain morphometric deviations in individuals at clinical high-risk for psychosis and finds they largely overlap with healthy variation and are not strongly associated with symptom severity or conversion to psychosis.

Intergenerational transmission of the patterns of functional and structural brain networks

The paper shows that functional and structural brain network patterns are preserved from parents to children and identifies demographic and behavioral factors affecting brain similarity.

Brain/MINDS Beyond Human Brain MRI Study: Multi-Site Harmonization for Brain Disorders Throughout the Lifespan

This paper outlines a multi-site MRI study aiming to establish harmonized imaging biomarkers for brain disorders across the lifespan using standardized protocols and data from healthy and patient subjects.

Functional connectome linking child-parent relationships with psychological problems in adolescence

The paper examines how paternal and maternal-child relationships affect brain connectivity and psychobehavioral problems in adolescents, finding sex-specific effects on aggression and internalizing issues.

Promoter activity-based case-control association study on SLC6A4 highlighting hypermethylation and altered amygdala volume in male patients with schizophrenia

The paper identifies hypermethylation of SLC6A4 in male schizophrenia patients and links it to reduced amygdala volume and 5-HTTLPR genotype.