Unprecedentedly efficient CUG initiation of an overlapping reading frame in POLG mRNA yields novel protein POLGARF
Gary Loughran, Alexander V. Zhdanov, Maria S. Mikhaylova, Fedor N. Rozov, Petr N. Datskevich, Sergey I. Kovalchuk, Marina V. Serebryakova, Stephen J. Kiniry, Audrey M. Michel, Patrick B. F. O’Connor, Dmitri B. Papkovsky, John F. Atkins, Pavel V. Baranov, Ivan N. Shatsky, Dmitry E. Andreev
The paper identifies a novel protein, POLGARF, encoded by an overlapping reading frame in POLG mRNA, showing efficient CUG initiation and evolutionary origins via MIR transposition.
Proceedings of the National Academy of Sciences · Sep 21, 2020Peer-reviewedMolecular Biology