Dmitry E. Andreev

Mitochondrial cytochrome c accumulation accompanies reduced electron flux through complex IV without enhancing cell sensitivity to apoptosis

The paper shows that reduced electron flux through complex IV leads to cytochrome c accumulation via increased stability and membrane retention, without increasing apoptosis sensitivity.

The earliest changes in the translatome upon human T cell activation

This study examines early transcriptional and translational changes in human T cells within four hours of activation, revealing dynamic gene expression and translation initiation patterns.

Thousands of human non-AUG extended proteoforms lack evidence of evolutionary selection among mammals

The paper identifies thousands of non-AUG initiated proteoforms in humans and mice, many lacking evolutionary selection evidence, using ribo-seq and phylogenetic analysis.

Unprecedentedly efficient CUG initiation of an overlapping reading frame in POLG mRNA yields novel protein POLGARF

The paper identifies a novel protein, POLGARF, encoded by an overlapping reading frame in POLG mRNA, showing efficient CUG initiation and evolutionary origins via MIR transposition.

TASEP modelling provides a parsimonious explanation for the ability of a single uORF to upregulate downstream ORF translation during the Integrated Stress Response

The paper develops a computational model to explain how a single upstream open reading frame (uORF) can upregulate downstream ORF translation during the Integrated Stress Response.