Anabolic sensitivity in healthy, lean, older men is associated with higher expression of amino acid sensors and mTORC1 activators
Oscar Horwath, Marcus Moberg, Nathan W. Hodson, Sebastian Edman, Mats Johansson, Eva A. Andersson, Gerrit van Hall, Olav Rooyackers, Andrew Philp, William Apró
This study shows that lean, healthy older men maintain anabolic sensitivity to amino acids and exercise, with increased mTORC1 signaling and muscle protein synthesis, suggesting aging alone does not cause anabolic resistance.
Journal of Cachexia Sarcopenia and Muscle · Nov 19, 2024Peer-reviewedPhysiology