Oscar Horwath

Reduced physiological reserve and a blunted response to acute exercise in adults with cerebral palsy

This study identifies a distinct cardiometabolic profile and reduced physiological response to exercise in adults with cerebral palsy compared to typically developing individuals.

Ageing blunts the phospho-proteomic response to resistance exercise in humans

This study shows that ageing reduces the phospho-proteomic response to resistance exercise in human skeletal muscle, despite normal mTORC1 activation, suggesting new therapeutic targets for aged muscle.

Comparable Strength and Hypertrophic Adaptations to Low-Load and High-Load Resistance Exercise Training in Trained Individuals: Many Roads Lead to Rome

This study compares low-load and high-load resistance training in trained individuals, finding comparable increases in strength and hypertrophy with LL-RET.

A glucosinolate-rich beverage lowers blood lactate concentrations during submaximal exercise

This study shows that consuming glucosinolate-rich red kale sprouts reduces blood lactate during submaximal cycling and increases resting blood glucose.

Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers

This study examines how endurance exercise with reduced muscle glycogen affects substrate utilization and signaling in human muscle fibers, finding altered fatty acid metabolism and mTORC1-autophagy dynamics.

Anabolic sensitivity in healthy, lean, older men is associated with higher expression of amino acid sensors and mTORC1 activators

This study shows that lean, healthy older men maintain anabolic sensitivity to amino acids and exercise, with increased mTORC1 signaling and muscle protein synthesis, suggesting aging alone does not cause anabolic resistance.