Andrea Comba

This study identifies autophagy as a critical survival pathway in mIDH1 gliomas and shows that inhibiting autophagy enhances radiosensitivity and tumor regression in preclinical models.

The paper uses an agent-based model to show that glioma cell morphology and density influence self-organization patterns like flocks and streams, with higher density reducing flocks and increasing streams, linking these patterns to tumor malignancy.