Maria Graciela Castro

This study identifies SWELL1-mediated D-2HG export as a mechanism for immune evasion and metabolic fitness in IDH-mutant gliomas, showing that inhibiting this pathway can suppress tumor growth and enhance immune response.

This study shows that inhibiting ATM signaling with AZD1390 improves radiation efficacy in H3K27M-altered diffuse midline glioma by enhancing DNA damage repair sensitivity.

This study shows that combining CD73 inhibition with immune-stimulatory gene therapy improves treatment efficacy for wtIDH1 gliomas.

This study identifies MIF-CD74 axis regulation of myeloid cells in gliomas and shows that MIF inhibition enhances immune therapy efficacy in wtIDH1 gliomas.

This study shows that HDL nanodiscs with LXR agonists and CpG oligonucleotides improve survival and reduce tumor burden in a mouse glioma model when combined with radiation.

The paper identifies 3D topological defects and quasi-long-range order in glioma tumors, linking them to tumor aggression and cell density regulation.

This study shows that CD200 depletion in gliomas enhances antitumor immunity and leads to tumor rejection by modulating immune cell activity and cytokine expression.

This study identifies autophagy as a critical survival pathway in mIDH1 gliomas and shows that inhibiting autophagy enhances radiosensitivity and tumor regression in preclinical models.

This paper models glioma oncostreams in vitro, showing their formation, stability, and response to pharmacological agents, with insights into potential anti-invasion targets.

This study shows that purine metabolism affects DNA repair and therapy resistance in glioblastoma, suggesting that targeting purine synthesis could improve treatment outcomes.