Polyamine Depletion by D, L-alpha-difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis
Rachel Offenbacher, Kyle W. Jackson, Masanori Hayashi, Jinghang Zhang, Da Peng, Yuqi Tan, Tracy Murray Stewart, Paul Ciero, Jackson R. Foley, Robert A. Casero, Patrick Cahan, David Mark Loeb
This study shows DFMO inhibits Ewing sarcoma metastasis by inducing ferroptosis through polyamine depletion.
Clinical Cancer Research · Jul 24, 2025Peer-reviewedCancer Biology