David Mark Loeb

DDX3 Regulates the Innate Immune Response to Bone Sarcomas

This study shows that inhibiting DDX3 in sarcomas induces a Type I interferon response and reduces metastasis when combined with immunostimulant therapy in mouse models.

Comprehensive single cell transcriptomics analysis of murine osteosarcoma uncovers Skp2 function in metastasis, genomic instability and immune activation and reveals additional target pathways

This study uses scRNA-seq to analyze murine osteosarcoma models and identifies Skp2's role in metastasis, genomic instability, and immune activation, revealing potential therapeutic targets.

Cycling Molecular Assemblies for Selective Cancer Cell Golgi Disruption

This paper develops CyMA, small peptides that disrupt cancer cell Golgi function by exploiting enzymatic cycles, showing selectivity over hepatocytes and immune cells.

Polyamine Depletion by D, L-alpha-difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis

This study shows DFMO inhibits Ewing sarcoma metastasis by inducing ferroptosis through polyamine depletion.

Inhibition Of One-Carbon Metabolism In Ewing Sarcoma Results In Profound And Prolonged Growth Suppression Associated With Purine Depletion

This study shows that inhibiting one-carbon metabolism in Ewing sarcoma cells leads to growth suppression through purine depletion, identifying a potential therapeutic target.

Inhibition of DKK-1 by WAY262611 Inhibits Osteosarcoma Metastasis

This study shows that the small molecule inhibitor WAY262611 inhibits osteosarcoma metastasis by activating Wnt signaling and inducing osteoblastic differentiation.