Enakshi Sinniah

Protocol-dependent cardiomyocyte states determine disease modelling capacity of human iPSCs

This study compares sixteen iPSC-CM differentiation protocols to identify how protocol-dependent cell states affect disease modeling capacity for cardiovascular conditions.

Interrogating the Regulatory Function of HAQERs during Human Cortical Development

The paper identifies HAQERs in human cortical development, showing their role in gene regulation through CpG gains and links them to neurological disorders.

Epigenetic constraint of cellular genomes evolutionarily links genetic variation to function

The paper identifies regions of the human genome under cellular constraint by analyzing chromatin accessibility across cell types, showing their predictive power for functional loci and applications in variant identification and drug discovery.

Inferring cell diversity in single cell data using consortium-scale epigenetic data as a biological anchor for cell identity

The paper introduces TRIAGE-Cluster and TRIAGE-ParseR to define cell diversity in scRNA-seq data using epigenetic data as a biological anchor.

A pluripotent stem cell atlas of multilineage differentiation reveals TMEM88 as a developmental regulator of mammalian blood pressure

The paper creates an iPSC differentiation atlas and identifies TMEM88 as a regulator of mesendodermal development and blood pressure.