Author

Nicole R. Hackel

Moffitt Cancer CenterORCID 0000-0002-3418-8545Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Elsa Renee FloresiD· 2 shared Eric B. HauraiD· 2 shared Hayley D. AckermaniD· 2 shared Jaden R Baldwin· 2 shared John H. LockhartiD· 2 shared John M. KoomeniD· 2 shared Michelle A. ReiseriD· 2 shared Paul A. StewartiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Elsa Renee FloresORCID

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2 papers

Recent·Most cited

Ex Vivo Culture of Patient-Derived Primary, Metastatic, and Post-Mortem Lung Cancer Reveals Targetable States of EMT and Metabolic Plasticity

Suehelay Acevedo‐Acevedo, Hayley D. Ackerman, Vanessa Y. Rubio, Nicole R. Hackel, Christina L. Carr, Kaitlyn Miranda, Jaden R Baldwin, Michelle A. Reiser, John H. Lockhart, Ashley Lui, Paul A. Stewart, X Yu, Gabriela M. Wright, Aileen Y. Alontaga, John M. Koomen, , Elsa Renee Flores

The paper develops microtumor models from lung cancer samples to study EMT and metabolic changes, identifying fatty acid synthesis as a targetable vulnerability.

bioRxiv · Jun 18, 2026 · PreprintCancer Biology

TAp73 mediates anti-tumor immunity through regulation of lipid metabolism in the lung tumor microenvironment

Hayley D. Ackerman, Vanessa Y. Rubio, Andrew John Davis, John H. Lockhart, Nicole R. Hackel, Rachel V. Jimenez, Rosa A. Sierra-Mondragon, Jaden R Baldwin, Christina Carr, Michelle A. Reiser, Marco Napoli, Xiaoqing Yu, Chia‐Ho Cheng, Paul A. Stewart, Suehelay Acevedo‐Acevedo, , Elsa Renee Flores

This study shows TAp73 regulates lipid metabolism in lung tumor microenvironment to enhance anti-tumor immunity through T-cell activation.

bioRxiv · Nov 21, 2025 · PreprintCancer Biology