Author

John H. Lockhart

Moffitt Cancer CenterORCID 0000-0002-2727-6969Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Elsa Renee FloresiD· 5 shared John M. KoomeniD· 3 shared Ana P. GomesiD· 2 shared Didem IlteriD· 2 shared Eric B. HauraiD· 2 shared Felicia Lazure· 2 shared Gina M. DeNicolaiD· 2 shared Hayley D. AckermaniD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersCancer Biology

Elsa Renee FloresORCID

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5 papers

Recent·Most cited

Ex Vivo Culture of Patient-Derived Primary, Metastatic, and Post-Mortem Lung Cancer Reveals Targetable States of EMT and Metabolic Plasticity

Suehelay Acevedo‐Acevedo, Hayley D. Ackerman, Vanessa Y. Rubio, Nicole R. Hackel, Christina L. Carr, Kaitlyn Miranda, Jaden R Baldwin, Michelle A. Reiser, John H. Lockhart, Ashley Lui, Paul A. Stewart, X Yu, Gabriela M. Wright, Aileen Y. Alontaga, John M. Koomen, , Elsa Renee Flores

The paper develops microtumor models from lung cancer samples to study EMT and metabolic changes, identifying fatty acid synthesis as a targetable vulnerability.

bioRxiv · Jun 18, 2026 · PreprintCancer Biology

TAp63-regulated oncogenic long non-coding RNA-8 ( TROLL-8 ) regulates human breast cancer progression through CPT1A-mediated fatty acid oxidation

Avani A. Deshpande, Marco Napoli, John H. Lockhart, Xiaobo Li, Min Liu, Lancia N. F. Darville, Bin Fang, John M. Koomen, Elsa Renee Flores

This study identifies TROLL-8 as a regulator of fatty acid oxidation in breast cancer, showing its role in promoting tumorigenesis through CPT1A interaction.

bioRxiv · Jun 15, 2026 · PreprintCancer Biology

Quinolinic acid phosphoribosyl transferase moonlights as an apoptosis regulator to empower lung cancer progression

Hossein Kashfi, Didem Ilter, Angelo A. Nicolaci, John H. Lockhart, Stanislav Drápela, Felicia Lazure, Devesh Raizada, Nadir Sarigul, Julia Spegel, Nathan P. Ward, Tumpa Dutta, Stephen J. Gardell, Jennifer M. Binning, Elsa Renee Flores, Gina M. DeNicola, Ana P. Gomes

This study identifies QPRT as a non-canonical apoptosis regulator in NSCLC that suppresses caspase-3 activation, independent of its role in NAD biosynthesis, suggesting it as a therapeutic target.

bioRxiv · Apr 3, 2026 · PreprintCancer Biology

TAp73 mediates anti-tumor immunity through regulation of lipid metabolism in the lung tumor microenvironment

Hayley D. Ackerman, Vanessa Y. Rubio, Andrew John Davis, John H. Lockhart, Nicole R. Hackel, Rachel V. Jimenez, Rosa A. Sierra-Mondragon, Jaden R Baldwin, Christina Carr, Michelle A. Reiser, Marco Napoli, Xiaoqing Yu, Chia‐Ho Cheng, Paul A. Stewart, Suehelay Acevedo‐Acevedo, , Elsa Renee Flores

This study shows TAp73 regulates lipid metabolism in lung tumor microenvironment to enhance anti-tumor immunity through T-cell activation.

bioRxiv · Nov 21, 2025 · PreprintCancer Biology

Aging directs the differential evolution of KRAS-driven lung adenocarcinoma

Felicia Lazure, Stanislav Drápela, Xiaoxian Liu, John H. Lockhart, Hossein Kashfi, Nadir Sarigul, Didem Ilter, Elsa Renee Flores, Xuefeng Wang, Inna Smalley, Alex M. Jaeger, Xiaoqing Yu, Ana P. Gomes

This study uses single-cell RNA-sequencing to show that aging promotes KRAS-driven lung adenocarcinoma evolution toward a stem-like state through age-related changes in the tumor microenvironment.

bioRxiv · Jan 20, 2025 · PreprintCancer Biology