Erythropoietin alleviates intellectual disability and autism-like behavior of mice caused by Zbtb20 haploinsufficiency, a construct-valid model of Primrose syndrome
Martin Hindermann, Justus B. H. Wilke, Yasmina Curto, Stefan N. Oline, Vinícius Daguano Gastaldi, Umer Javed Butt, Rakshit Dadarwal, Umut Çakır, Anja Ronnenberg, Kurt Hammerschmidt, Susann Boretius, Anastassia Stoykova, Anton B. Tonchev, Klaus‐Armin Nave, Manvendra Singh, Hannelore Ehrenreich
This study shows that erythropoietin treatment improves behavioral and phenotypical symptoms in Zbtb20+/- mice, a model of Primrose syndrome.
bioRxiv · Sep 11, 2025 · PreprintNeuroscience