Hannelore Ehrenreich

This study uses snATAC-seq and snRNA-seq to identify TE-derived regulatory elements involved in adult hippocampal neurogenesis in response to rhEPO stimulation.

This study identifies HIF1A's role in recruiting primate-specific endogenous retroviruses into hypoxic and immune responses, revealing their regulatory impact on gene expression.

The paper introduces co-expression-based models to improve eQTL predictions and identifies novel schizophrenia-associated genes using brain RNA-seq data.

This study shows EPO induces chromatin remodeling in adult mouse hippocampal neurons, revealing a transposon-mediated mechanism for neurogenesis.

The paper shows that deleting EPO in the forebrain of mice leads to increased expression of EPOR and EphB4, which may explain the lack of cognitive deficits in these mutants.

This study investigates how erythropoietin (EPO) and its receptor (EPOR) regulate oligodendrocyte lineage dynamics in the adult mouse hippocampus, showing EPO promotes differentiation and maturation, and suggests potential therapeutic applications for remyelination.

This study shows that erythropoietin treatment improves behavioral and phenotypical symptoms in Zbtb20+/- mice, a model of Primrose syndrome.

IntelliR is a pipeline for analyzing IntelliCage data, enabling automated assessment of spatial, episodic-like, and working memory in mice, with validation using control and neuron-ablated cohorts.

The paper simulates non-local information processing in associative brain regions using holographic wave patterns and compares results with electrophysiology and EEG data.

The paper identifies genetically distinct patient subgroups across diseases by analyzing polygenic risk and pathway convergence.

This study shows that erythropoietin (EPO) reduces inhibitory potential in hippocampal interneurons, enhancing pyramidal neuron excitability and potentially improving neuropsychiatric symptoms.

This study shows that ageing-related myelin dysfunction drives amyloid-beta deposition in Alzheimer's disease mouse models, suggesting myelin integrity as an upstream risk factor.

This study uses single-nucleus RNA sequencing to show that erythropoietin treatment restructures transcriptional networks in hippocampal pyramidal neurons, increasing their numbers and altering gene expression related to neurodifferentiation and cognition.

This study shows that forebrain-specific myelin loss in mice causes catatonia-like symptoms and isolated executive dysfunction without affecting motor-sensory functions.

This study shows that Ambra1 heterozygosity causes sex-specific reductions in excitatory synaptic activity, leading to E/I imbalance and autism-like behaviors in female mice.

The paper shows that myelin acts as an energy reserve in the brain under glucose deprivation, supporting oligodendrocytes and axons through fatty acid oxidation.

A neural model of non-local information processing on a neocolumnar architecture replicates electrophysiological data from primates, showing high-frequency activity during visual perception.

This study shows that continuous myelin synthesis is necessary for maintaining white matter integrity, as preventing new myelin formation in adult mice leads to myelin degradation and neurological disease.

This study uses genome-wide association data for educational attainment and schizophrenia to identify genetic heterogeneity and novel candidate genes for schizophrenia.

The paper shows that placental gene expression mediates the interaction between obstetrical history and genetic risk for schizophrenia, with ELCs enhancing PRS effects.