Manvendra Singh

This study uses snATAC-seq and snRNA-seq to identify TE-derived regulatory elements involved in adult hippocampal neurogenesis in response to rhEPO stimulation.

This study identifies HIF1A's role in recruiting primate-specific endogenous retroviruses into hypoxic and immune responses, revealing their regulatory impact on gene expression.

The paper introduces BioChirp, a system for reliable retrieval of structured biomedical data, outperforming existing agentic NL2SQL systems in accuracy and consistency.

The paper identifies retroviral elements LTR8B and MER65 that regulate PSG9 expression, influencing trophoblast syncytialization and pre-eclampsia risk.

This study shows EPO induces chromatin remodeling in adult mouse hippocampal neurons, revealing a transposon-mediated mechanism for neurogenesis.

The paper shows that deleting EPO in the forebrain of mice leads to increased expression of EPOR and EphB4, which may explain the lack of cognitive deficits in these mutants.

This study investigates how erythropoietin (EPO) and its receptor (EPOR) regulate oligodendrocyte lineage dynamics in the adult mouse hippocampus, showing EPO promotes differentiation and maturation, and suggests potential therapeutic applications for remyelination.

This study shows that erythropoietin treatment improves behavioral and phenotypical symptoms in Zbtb20+/- mice, a model of Primrose syndrome.

This study shows that erythropoietin (EPO) reduces inhibitory potential in hippocampal interneurons, enhancing pyramidal neuron excitability and potentially improving neuropsychiatric symptoms.

This study shows PNMA2 forms virus-like capsids that trigger an autoimmune response, leading to paraneoplastic neurological syndrome.

This study uses single-nucleus RNA sequencing to show that erythropoietin treatment restructures transcriptional networks in hippocampal pyramidal neurons, increasing their numbers and altering gene expression related to neurodifferentiation and cognition.

The paper identifies a human protein of retroviral origin that restricts retroviral infection, showing its expression in embryos and placenta and its antiviral activity against type D retroviruses.

The paper identifies a regulatory loop between MITF and HERV-K Rec that influences melanoma progression from proliferative to invasive stages.

The paper maps human coronavirus entry factors using single-cell RNA-seq to identify permissive cell types and tissues for SARS-CoV-2 infection.

This study identifies HMGXB4 as a regulator of Sleeping Beauty transposition in vertebrate germinal stem cells, linking it to chromatin dynamics and stemness maintenance during early development.

This study shows HERV-K(HML-2) RNA activates TLR8 and Tlr7, causing neurodegeneration in mice and correlating with AD in humans.

The paper identifies Pclo mutations in rats that affect reproductive behavior and link to depression-associated genes.

The paper reanalyzes single-cell transcriptomic data and in situ stains to reveal the presence of a transcriptomically homologous inner cell mass in human blastocysts, highlighting unique developmental and evolutionary features.