Author

Dayne L. Filer

University of North Carolina at Chapel HillORCID 0000-0002-3443-5315Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Kirk C. WilhelmseniD· 2 shared Alicia BrandtiD· 1 shared Anders BjörkmaniD· 1 shared Andreas MårtenssoniD· 1 shared Andrew Parker MorganiD· 1 shared Billy NgasalaiD· 1 shared Bradford C. PowelliD· 1 shared Clark D. JeffriesiD· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Kirk C. WilhelmsenORCID

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3 papers

Recent·Most cited

Noninvasive prenatal exome sequencing inefficient for detecting single-gene disorders -- problems and possible solutions

Dayne L. Filer, Piotr A. Mieczkowski, Alicia Brandt, Kelly L. Gilmore, Bradford C. Powell, Jonathan S. Berg, Kirk C. Wilhelmsen, Neeta L. Vora

This study shows exome sequencing of cell-free DNA is limited by technical issues and sampling challenges, making it unsuitable for noninvasive prenatal detection of single-gene disorders.

medRxiv · Aug 4, 2020 · PreprintGenetic & Genomic Medicine

Frisky CALF sometimes outruns LASSO

Clark D. Jeffries, John R. Ford, Jeffrey L. Tilson, Diana O. Perkins, Darius M. Bost, Dayne L. Filer, Kirk C. Wilhelmsen

The paper introduces CALF, a linear regression method that outperforms LASSO in several metrics on real medical data.

bioRxiv · Mar 27, 2020 · PreprintBioinformatics

Falciparum malaria from coastal Tanzania and Zanzibar remains highly connected despite effective control efforts on the archipelago

Andrew Parker Morgan, Nicholas F. Brazeau, Billy Ngasala, Lwidiko Edward Mhamilawa, Madeline Denton, Mwinyi I. Msellem, Ulrika Morris, Dayne L. Filer, Özkan Aydemir, Jeffrey A. Bailey, Jonathan B. Parr, Andreas Mårtensson, Anders Björkman, Jonathan J. Juliano

The paper uses whole-genome sequencing to show that Plasmodium falciparum parasites in Zanzibar and mainland Tanzania share genetic ancestry, indicating ongoing importation despite malaria control efforts.

Malaria Journal · Jan 28, 2020Peer-reviewedGenetics