Piotr A. Mieczkowski

The paper describes a penta-omic sequential extraction method for post-mortem human brain samples, showing minimal omic loss and preserved tissue integrity compared to single-omic methods.

This study compares genome instability in articular chondrocytes and skin fibroblasts using whole-genome sequencing, revealing distinct mutation patterns and mutagenic mechanisms between the two cell types.

This study identifies molecular mechanisms of strobilurin resistance in Moniliophthora perniciosa, revealing metabolic and genetic changes that enable tolerance to these fungicides.

This study shows methylglyoxal mutagenizes single-stranded DNA through Rev1-mediated slippage and mispairing, with mutations enriched in tumor datasets.

This study identifies DNA repair pathways that prevent acetaldehyde-induced mutagenesis in yeast and corroborates findings in human liver cancers.

The paper identifies a microbial-derived metabolite, DHPS, and its associated bacterial taxa linked to three neurodegenerative diseases, suggesting a role for sulfur metabolism in disease progression.

This study identifies molecular changes in astrocytes of the nucleus accumbens in rats following cocaine self-administration and abstinence using RiboTag and RNA-seq.

This study shows that MutL suppresses error-prone DNA mismatch repair and protects noncoding DNA from mutations in yeast and human cells.

This study shows acetaldehyde causes strand-biased G[->]T mutations on single-stranded DNA via Polζ bypass and identifies a unique mutation signature in alcohol-related cancers.

This study shows the yeast Shu complex prevents mutagenesis from 3meC lesions by binding to them and reducing replication errors.

The paper reports genomic sequences of six Mucoromycotina fungi and an associated bacterium, linking genomic diversity to metabolic traits and ecological features.

The paper characterizes bursts of genome-wide loss-of-heterozygosity in budding yeast, showing non-independent mutation accumulation and systemic genomic instability.

This study shows exome sequencing of cell-free DNA is limited by technical issues and sampling challenges, making it unsuitable for noninvasive prenatal detection of single-gene disorders.

The paper identifies systemic genomic instability in yeast, showing non-independent accumulation of loss-of-heterozygosity events across multiple chromosomes.