Author

G. Andrew Woolley

University of TorontoORCID 0000-0002-3446-2639Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:protein structure· 2 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Organism:yeast· 1

Frequent Co-Authors

Maruti UppalapatiiD· 3 shared Giang N. T. LeiD· 2 shared Jaewan Jang· 2 shared Kun TangiD· 2 shared Matias Daniel ZurbriggeniD· 2 shared Boyan Xue· 1 shared Hannes Michael BeyeriD· 1 shared Jeffrey Youn· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersSynthetic Biology

Maruti UppalapatiORCID

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3 papers

Recent·Most cited

An ultra-low background far-red light-responsive optogenetic tool based on an engineered biliverdin-binding domain

Giang N. T. Le, Lam M. T. Pham, Boyan Xue, Maruti Uppalapati, G. Andrew Woolley

The paper develops a small, monomeric, far-red light-responsive optogenetic tool with high affinity and low background binding for use in mammalian cells.

Nature Methods · Sep 11, 2026Peer-reviewedSynthetic Biology

Red-light-only control of protein-protein interactions using a cyanobacteriochrome (UNICYCL)

Giang N. T. Le, P. Maximilian M. Reed, Jaewan Jang, Kun Tang, Matias Daniel Zurbriggen, Maruti Uppalapati, G. Andrew Woolley

This paper introduces a small red-light-responsive system for controlling protein-protein interactions using a cyanobacteriochrome, showing a >25-fold decrease in binding affinity under red light.

ACS Central Science · Jan 20, 2026Peer-reviewedBiochemistry

Green, orange, red, and far-red optogenetic tools derived from cyanobacteriochromes

Jaewan Jang, Kun Tang, Jeffrey Youn, Sherin McDonald, Hannes Michael Beyer, Matias Daniel Zurbriggen, Maruti Uppalapati, G. Andrew Woolley

The paper develops optogenetic tools that control protein-protein interactions using light in multiple colors by engineering binders for different states of cyanobacteriochromes.

Nature Methods · Feb 23, 2023Peer-reviewedSynthetic Biology