Giang N. T. Le

An ultra-low background far-red light-responsive optogenetic tool based on an engineered biliverdin-binding domain

The paper develops a small, monomeric, far-red light-responsive optogenetic tool with high affinity and low background binding for use in mammalian cells.

Red-light-only control of protein-protein interactions using a cyanobacteriochrome (UNICYCL)

This paper introduces a small red-light-responsive system for controlling protein-protein interactions using a cyanobacteriochrome, showing a >25-fold decrease in binding affinity under red light.

Improved genetically encoded fluorescent biosensors for monitoring of intra- and extracellular L-lactate

This paper develops improved fluorescent biosensors for monitoring extracellular and intracellular L-lactate in mammalian cells, showing enhanced sensitivity and response kinetics.