Maruti Uppalapati

The paper develops a small, monomeric, far-red light-responsive optogenetic tool with high affinity and low background binding for use in mammalian cells.

This paper introduces a small red-light-responsive system for controlling protein-protein interactions using a cyanobacteriochrome, showing a >25-fold decrease in binding affinity under red light.

This study develops and evaluates Zr-labeled N4MU01 radioimmunoconjugates for imaging and radiotherapy of nectin-4 positive triple-negative breast cancer, showing promising tumor uptake and therapeutic efficacy.

The paper develops optogenetic tools that control protein-protein interactions using light in multiple colors by engineering binders for different states of cyanobacteriochromes.