Cell type-Specific In Vivo Proteomes with a Multi-copy Mutant Methionyl t-RNA Synthetase Mouse Line
Rodrigo Alvarez-Pardo, Susanne tom Dieck, Kristina Desch, Belquis Nassim-Assir, Cristina Olmedo Salinas, Riya S. Sivakumar, Julian D. Langer, Erin Margaret Schuman, Beatriz Alvarez‐Castelao
This paper introduces a multicopy MetRS* mouse line to enhance cell type-specific in vivo protein labeling, enabling sensitive detection of newly synthesized proteins in sparse cell populations.
Lab Animal · Aug 13, 2025Peer-reviewedCell Biology