Author

Karanvir Saini

University of PennsylvaniaORCID 0000-0002-3451-2499Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:experimental assay· 1 Assay:imaging· 1 Organism:non-human primate· 1 Approach:statistical model· 1 Organism:zebrafish· 1

Frequent Co-Authors

David M. ChenowethiD· 2 shared Dennis E. DischeriD· 2 shared Sangkyun ChoiD· 2 shared A. Jalil· 1 shared AA.R. Jalil· 1 shared Alex Kasznel· 1 shared Alexander J. KaszneliD· 1 shared Cory M. AlveyiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMolecular Biology

David M. ChenowethORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 27, 2023

Pan-tissue scaling of stiffness versus fibrillar collagen reflects contractility-driven strain that inhibits fibril degradation

Karanvir Saini, Sangkyun Cho, Manu Tewari…·Dennis E. Discher

The paper examines how tissue stiffness scales with collagen levels across different tissues and finds sub-linear scaling that aligns with cellularized gels, suggesting contractility-driven strain inhibition of collagen degradation.

1 citation

mousezebrafish

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Molecular BiologybioRxivPreprintFeb 7, 2021

Heterogeneous strains in tissue collagen show that high strains locally suppress degradation by collagenase

Karanvir Saini, M. Tiwari, Sangkyun Cho…·Dennis E. Discher

This paper investigates how mechanical strain affects collagen degradation in tendon and heart tissues, finding that moderate strains suppress degradation while higher strains do not.

5 citations

mousenon-human primate

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