Heterogeneous strains in tissue collagen show that high strains locally suppress degradation by collagenase
Karanvir Saini, M. Tiwari, Sangkyun Cho, A. Jalil, Manasvita Vashisth, Jerome Irianto, Jason C. Andrechak, Lawrence J. Dooling, Cory M. Alvey, Alex Kasznel, David M. Chenoweth, K. Yamamoto, Dennis E. Discher
This paper investigates how mechanical strain affects collagen degradation in tendon and heart tissues, finding that moderate strains suppress degradation while higher strains do not.
bioRxiv · Feb 7, 2021 · PreprintMolecular Biology