Pharmacology & ToxicologyNature CommunicationsPeer-reviewed
Inactive structures of the vasopressin V2 receptor reveal distinct antagonist binding modes for Tolvaptan and Mambaquaretin toxin
Aurélien Fouillen, Julien Bous, Pierre Couvineau…·Bernard Mouillac
The paper solves cryo-EM structures of the V2R bound to Tolvaptan and Mambaquaretin toxin, revealing distinct antagonist binding modes and inactive conformations.
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