Paul A. Sigala

The paper uses evolutionary rate covariation across malaria parasite species to infer protein interactions and identify new functional candidates.

This study shows that Acyl Carrier Protein (ACP) is essential for apicoplast biogenesis in blood-stage P. falciparum malaria parasites, independent of its role in fatty acid synthesis.

The paper identifies a putative metal transporter in the apicoplast of malaria parasites, showing it is essential for gametocyte development but not asexual stages.

The paper identifies a divergent cytochrome c in malaria parasites with an unusually low redox potential, suggesting a novel biochemical role outside the canonical electron transport chain function.

This paper identifies hydrogen peroxide-driven catalytic motion of hemozoin crystals in malaria parasites, revealing them as self-propelled nanoparticles that reduce oxidative stress.

This study identifies PfHO as essential for apicoplast biogenesis and gene expression in Plasmodium falciparum, revealing its role in maintaining apicoplast-encoded RNA levels.

This study identifies PfDMT1 as a critical iron transporter in malaria parasites, showing its essential role in iron acquisition and its potential as a therapeutic target.

This study investigates the role of HCCS and HCC1S in cytochrome c and c1 biogenesis in malaria parasites, revealing their distinct specificities and essential functions in the mitochondrial electron transport chain.