Oxidative stress underlies heritable impacts of paternal cigarette smoke exposure
Patrick J. Murphy, Jingtao Guo, Timothy G. Jenkins, Emma Rae James, John R. Hoidal, Thomas P. Huecksteadt, Dallin S. Broberg, James Morris Hotaling, David Alonso, Douglas T. Carrell, Bradley Robert Cairns, Kenneth Ivan Aston
This study shows paternal cigarette smoke exposure alters sperm DNA methylation and offspring gene expression, with oxidative stress mediating these heritable changes.
bioRxiv · Oct 30, 2019 · PreprintGenetics