Timothy G. Jenkins

The paper identifies AluY epimutations in sperm from men with unexplained recurrent pregnancy loss, showing they are enriched in hypomethylated regions and linked to genes involved in early development.

The paper introduces ModSeqR, an R package that enables efficient analysis of modified nucleotide data using a new CH3 file format to reduce storage and computational demands.

The paper examines age-related changes in the human sperm methylome, finding that donor variability outweighs age effects, but age-dependent changes exist and vary by genomic location.

The paper assesses DNA methylation variability in gene promoters across tissues and disease states, finding tissue-specific patterns that can differentiate healthy from diseased tissue and predict fertility outcomes in male infertility.

This study identifies genetic subforms of non-obstructive azoospermia using exome sequencing and single-cell RNA sequencing, revealing molecular groups of genes involved in spermatogenesis.

The paper identifies de novo mutations as a significant genetic cause of male infertility, finding several candidate genes and an enrichment of loss-of-function and missense mutations in intolerant genes.

This study shows paternal cigarette smoke exposure alters sperm DNA methylation and offspring gene expression, with oxidative stress mediating these heritable changes.

This paper develops a DNA methylation age prediction model for human sperm, achieving high accuracy and repeatability, and identifies smoking as a subtle factor affecting sperm aging.