Douglas T. Carrell

The Human Infertility Single-cell Testis Atlas (HISTA): An interactive molecular scRNA-Seq reference of the human testis.

The paper introduces HISTA, an interactive scRNA-seq reference for the human testis, and demonstrates its use in analyzing lncRNA regulation and NANOS gene function in spermatogenesis.

Diverse Monogenic Subforms of Human Spermatogenic Failure

This study identifies genetic subforms of non-obstructive azoospermia using exome sequencing and single-cell RNA sequencing, revealing molecular groups of genes involved in spermatogenesis.

A de novo paradigm for male infertility

The paper identifies de novo mutations as a significant genetic cause of male infertility, finding several candidate genes and an enrichment of loss-of-function and missense mutations in intolerant genes.

Oxidative stress underlies heritable impacts of paternal cigarette smoke exposure

This study shows paternal cigarette smoke exposure alters sperm DNA methylation and offspring gene expression, with oxidative stress mediating these heritable changes.

Paternal germ line aging: DNA methylation age prediction from human sperm

This paper develops a DNA methylation age prediction model for human sperm, achieving high accuracy and repeatability, and identifies smoking as a subtle factor affecting sperm aging.