Jingtao Guo

GeneCompass is a cross-species foundation model pre-trained on single-cell transcriptomes from human and mouse, integrating biological knowledge to improve gene regulatory mechanism understanding and downstream tasks.

The paper introduces HISTA, an interactive scRNA-seq reference for the human testis, and demonstrates its use in analyzing lncRNA regulation and NANOS gene function in spermatogenesis.

This study identifies genetic subforms of non-obstructive azoospermia using exome sequencing and single-cell RNA sequencing, revealing molecular groups of genes involved in spermatogenesis.

This study uses spatial transcriptomics to create a spatial atlas of testis gene expression, identifying spatially segregated spermatogonial populations and disruptions in diabetic testes.

This study uses single-cell RNA-seq to analyze age-related changes in human testis and finds that dysregulation correlates with BMI in older men.

This study shows paternal cigarette smoke exposure alters sperm DNA methylation and offspring gene expression, with oxidative stress mediating these heritable changes.