James Morris Hotaling

Colibactin-associated mutations in the human colon appear to reflect anatomy and early exposure, not oncogenesis

The paper analyzes mutations in colon crypts to determine if colibactin is linked to early-onset CRC, finding that its association reflects anatomy rather than oncogenesis.

The Human Infertility Single-cell Testis Atlas (HISTA): An interactive molecular scRNA-Seq reference of the human testis.

The paper introduces HISTA, an interactive scRNA-seq reference for the human testis, and demonstrates its use in analyzing lncRNA regulation and NANOS gene function in spermatogenesis.

A tissue specific atlas of gene promoter DNA methylation variability and the clinical value of its assessment

The paper assesses DNA methylation variability in gene promoters across tissues and disease states, finding tissue-specific patterns that can differentiate healthy from diseased tissue and predict fertility outcomes in male infertility.

Diverse Monogenic Subforms of Human Spermatogenic Failure

This study identifies genetic subforms of non-obstructive azoospermia using exome sequencing and single-cell RNA sequencing, revealing molecular groups of genes involved in spermatogenesis.

A de novo paradigm for male infertility

The paper identifies de novo mutations as a significant genetic cause of male infertility, finding several candidate genes and an enrichment of loss-of-function and missense mutations in intolerant genes.

Single-Cell Analysis of Human Testis Aging, and Impact of Elevated Body Mass Index

This study uses single-cell RNA-seq to analyze age-related changes in human testis and finds that dysregulation correlates with BMI in older men.

Oxidative stress underlies heritable impacts of paternal cigarette smoke exposure

This study shows paternal cigarette smoke exposure alters sperm DNA methylation and offspring gene expression, with oxidative stress mediating these heritable changes.