Mechanistic Heterogeneity in Type 2 Diabetes and Hypertension Comorbidity Revealed with Partitioned Polygenic Scores
Vincent Pascat, Liudmila Zudina, Lucas Maurin, Anna Ulrich, Jared G. Maina, Ayşe Demirkan, Zhanna Balkhiyarova, Igor Pupko, Yevheniya Sharhorodska, François N. Pattou, Bart Staels, Marika Kaakinen, Amna Khamis, Amélie Bonnefond, Patricia B. Munroe, , Inga Prokopenko
The paper identifies genetic clusters underlying T2D and hypertension comorbidity using partitioned polygenic scores, improving risk prediction for individuals with heightened susceptibility.
medRxiv · Mar 2, 2025 · PreprintGenetic & Genomic Medicine