Cancer BiologyCancer ResearchPeer-reviewed
Metastasis-initiating osteosarcoma subpopulations establish paracrine interactions with both lung and tumor cells to create a metastatic niche
James Brandon Reinecke, Leyre Jimenez Garcia, Amanda J. Saraf…·Ryan David Roberts
This study identifies metastasis-initiating osteosarcoma subpopulations that interact with lung and tumor cells to form a metastatic niche, highlighting tumor-stromal interactions as key drivers of metastasis.