Author

James Brandon Reinecke

Nationwide Children's HospitalORCID 0000-0002-6498-7479Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Amy C. GrossiD· 2 shared Leyre Jimenez GarciaiD· 2 shared Maren CamiD· 2 shared Matthew J. GustiD· 2 shared Matthew V. CannoniD· 2 shared Ryan David RobertsiD· 2 shared Amanda J. SarafiD· 1 shared Berkley E. GryderiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBioinformatics

Amy C. GrossORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJan 28, 2026

SCANBIT facilitates identification of tumor cell populations in scRNAseq data using pseudobulked SNV calls

Matthew V. Cannon, Matthew J. Gust, Amy C. Gross…·Ryan David Roberts

SCANBIT identifies tumor cell populations in scRNA-seq data by using pseudobulked SNV calls, showing that mutational burden affects identification accuracy.

DOI 10.64898/2026.01.27.701834

humanscRNA-seq

𝕏 PostBluesky

Cancer BiologyCancer ResearchPeer-reviewedAug 29, 2025

Metastasis-initiating osteosarcoma subpopulations establish paracrine interactions with both lung and tumor cells to create a metastatic niche

James Brandon Reinecke, Leyre Jimenez Garcia, Amanda J. Saraf…·Ryan David Roberts

This study identifies metastasis-initiating osteosarcoma subpopulations that interact with lung and tumor cells to form a metastatic niche, highlighting tumor-stromal interactions as key drivers of metastasis.

15 citationstop 3%

mousescRNA-seq

𝕏 PostBluesky