Author

Leyre Jimenez Garcia

Nationwide Children's HospitalORCID 0009-0006-7281-1381Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:scRNA-seq· 3 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Amy C. GrossiD· 3 shared James Brandon ReineckeiD· 3 shared Maren CamiD· 3 shared Matthew J. GustiD· 3 shared Matthew V. CannoniD· 3 shared Ryan David RobertsiD· 3 shared Berkley E. GryderiD· 2 shared Ruben DriesiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersCancer Biology

Amy C. GrossORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJan 28, 2026

SCANBIT facilitates identification of tumor cell populations in scRNAseq data using pseudobulked SNV calls

Matthew V. Cannon, Matthew J. Gust, Amy C. Gross…·Ryan David Roberts

SCANBIT identifies tumor cell populations in scRNA-seq data by using pseudobulked SNV calls, showing that mutational burden affects identification accuracy.

DOI 10.64898/2026.01.27.701834

humanscRNA-seq

𝕏 PostBluesky

Cancer BiologyCancer ResearchPeer-reviewedAug 29, 2025

Metastasis-initiating osteosarcoma subpopulations establish paracrine interactions with both lung and tumor cells to create a metastatic niche

James Brandon Reinecke, Leyre Jimenez Garcia, Amanda J. Saraf…·Ryan David Roberts

This study identifies metastasis-initiating osteosarcoma subpopulations that interact with lung and tumor cells to form a metastatic niche, highlighting tumor-stromal interactions as key drivers of metastasis.

15 citationstop 3%

mousescRNA-seq

𝕏 PostBluesky

Cancer BiologyClinical Cancer ResearchPeer-reviewedNov 14, 2024

Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cells

James Brandon Reinecke, Leyre Jimenez Garcia, Amy C. Gross…·Ryan David Roberts

This study identifies fibrosis as a targetable vulnerability in osteosarcoma lung metastasis by showing nintedanib inhibits metastatic progression through anti-fibrotic effects.

26 citationstop 4%

mousescRNA-seq

𝕏 PostBluesky