Oriana Romano

SpaceTrooper provides a data-driven quality control framework for imaging-based spatial omics data, improving clustering and cell-type coherence by identifying low-quality cells without fixed thresholds.

This study uses multiplex base editing to target BCL11A enhancers, increasing fetal hemoglobin production and reducing sickle cell disease symptoms without causing significant genomic damage.

Preclinical safety and efficacy studies of a new gene therapy approach for patients with severe β-hemoglobinopathies.

This study develops a bifunctional lentiviral vector for sickle cell disease that combines gene addition and gene silencing to reduce HbS levels and improve treatment efficacy.