Alexandra Tachtsidi

This paper introduces TILV, a CRISPR-assisted method for precise targeted integration of transgenes in human hematopoietic stem cells using IDLV donors, showing improved efficiency and minimal impact on cell viability.

This study uses multiplex base editing to target BCL11A enhancers, increasing fetal hemoglobin production and reducing sickle cell disease symptoms without causing significant genomic damage.

Preclinical safety and efficacy studies of a new gene therapy approach for patients with severe β-hemoglobinopathies.

The paper identifies a genetic circuitry where OCT4 activates an antisense lncRNA that represses Suv39h1, linking H3K9 methylation levels to pluripotency in mouse ES cells.

The paper shows that CTCF and Esrrb maintain nucleosome positioning at gene regulatory regions during DNA replication and mitosis in mouse ES cells.

The paper investigates how transcription factors maintain gene regulatory information during mitosis by comparing fixation methods and analyzing nucleosome organization.